Onimusha 3 is the third game of the Onimusha series. The game retains elements from previous games in the franchise including the use of multiple special weapons in order to fight enemies and absorb their energy to enhance the weaponry. This time the player primarily controls both Samanosuke and Jacques in separate scenarios. The two are able to exchange items in order to solve puzzles. The development from this game started after the release of the PlayStation 2 which allowed the team to work on a 3D engine to design 3D backgrounds. In order to appeal to the Western market, the team set this game in Paris and chose French actor Jean Reno to portray Jacques. Onimusha 3 has been generally well received by publications for video games. Most of the writer's praise focused on the improved controls and the use of a 3D engine that allowed better combat and visuals, respectively. The game also generated good sales with over 1. 5 million copies sold as of May 2008.

A história se concentra no herói que retorna, o espadachim Hidemitsu Samanosuke Akechi, que está em sua busca para derrotar seu inimigo, Nobunaga Oda, que deseja conquistar o Japão com seu exército de demônios conhecido como Genma. No entanto, Samanosuke muda de lugar com um oficial francês do futuro chamado Jacques Blanc, e ambos têm que se adaptar aos seus novos mundos para se livrar de Nobunaga e dos Genma.