After Elexis Sinclaire disappeared at the end of Sin, Wages of Sin continues the storyline by introducing the new villain Gianni Manero, a mob boss who seeks to gain power from the leftovers of Elexis' former company SinTEK. Manero produces new genetically engineered creatures (mutants) under secret supervision, but when some of these mutants break out and run into the city, the elite security force group HARDCORPS becomes aware of them and it's up to HARDCORPS leader John Blade, who starred as the hero and the player's character in Sin, to set things right.